{
  "url": "https://dantelabs.com/traits/abnormal-thrombosis",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-thrombosis",
    "id": "HP:0001977",
    "name": "Abnormal blood clot",
    "label": "Abnormal thrombosis",
    "definition": "Venous or arterial thrombosis (formation of blood clots) of spontaneous nature and which cannot be fully explained by acquired risk (e.g. atherosclerosis).",
    "synonyms": [
      "Abnormal blood clotting"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "narrower": [
      {
        "slug": "thromboembolism",
        "name": "Thromboembolism",
        "genes": 51,
        "url": "https://dantelabs.com/traits/thromboembolism"
      },
      {
        "slug": "venous-thrombosis",
        "name": "Blood clot in vein",
        "genes": 50,
        "url": "https://dantelabs.com/traits/venous-thrombosis"
      },
      {
        "slug": "arterial-thrombosis",
        "name": "Blood clot in artery",
        "genes": 33,
        "url": "https://dantelabs.com/traits/arterial-thrombosis"
      },
      {
        "slug": "disseminated-intravascular-coagulation",
        "name": "Disseminated intravascular coagulation",
        "genes": 29,
        "url": "https://dantelabs.com/traits/disseminated-intravascular-coagulation"
      },
      {
        "slug": "peripheral-thrombosis",
        "name": "Peripheral blood clot",
        "genes": 4,
        "url": "https://dantelabs.com/traits/peripheral-thrombosis"
      },
      {
        "slug": "left-ventricular-thrombus",
        "name": "Left ventricular thrombus",
        "genes": 1,
        "url": "https://dantelabs.com/traits/left-ventricular-thrombus"
      }
    ],
    "genes": [
      {
        "slug": "bmpr2",
        "symbol": "BMPR2",
        "hgnc": "HGNC:1078",
        "name": "bone morphogenetic protein receptor type 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bmpr2"
      },
      {
        "slug": "mpi",
        "symbol": "MPI",
        "hgnc": "HGNC:7216",
        "name": "mannose phosphate isomerase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mpi"
      },
      {
        "slug": "rft1",
        "symbol": "RFT1",
        "hgnc": "HGNC:30220",
        "name": "RFT1 glycolipid translocator homolog",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rft1"
      },
      {
        "slug": "calr",
        "symbol": "CALR",
        "hgnc": "HGNC:1455",
        "name": "calreticulin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/calr"
      },
      {
        "slug": "f12",
        "symbol": "F12",
        "hgnc": "HGNC:3530",
        "name": "coagulation factor XII",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/f12"
      },
      {
        "slug": "jak2",
        "symbol": "JAK2",
        "hgnc": "HGNC:6192",
        "name": "Janus kinase 2",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/jak2"
      },
      {
        "slug": "mpl",
        "symbol": "MPL",
        "hgnc": "HGNC:7217",
        "name": "MPL proto-oncogene, thrombopoietin receptor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mpl"
      },
      {
        "slug": "mthfr",
        "symbol": "MTHFR",
        "hgnc": "HGNC:7436",
        "name": "methylenetetrahydrofolate reductase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mthfr"
      },
      {
        "slug": "pik3ca",
        "symbol": "PIK3CA",
        "hgnc": "HGNC:8975",
        "name": "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pik3ca"
      },
      {
        "slug": "rhag",
        "symbol": "RHAG",
        "hgnc": "HGNC:10006",
        "name": "Rh associated glycoprotein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rhag"
      },
      {
        "slug": "tet2",
        "symbol": "TET2",
        "hgnc": "HGNC:25941",
        "name": "tet methylcytosine dioxygenase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tet2"
      },
      {
        "slug": "cftr",
        "symbol": "CFTR",
        "hgnc": "HGNC:1884",
        "name": "CF transmembrane conductance regulator",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cftr"
      },
      {
        "slug": "ctrc",
        "symbol": "CTRC",
        "hgnc": "HGNC:2523",
        "name": "chymotrypsin C",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctrc"
      },
      {
        "slug": "hrg",
        "symbol": "HRG",
        "hgnc": "HGNC:5181",
        "name": "histidine rich glycoprotein",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hrg"
      },
      {
        "slug": "myh9",
        "symbol": "MYH9",
        "hgnc": "HGNC:7579",
        "name": "myosin heavy chain 9",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myh9"
      },
      {
        "slug": "prss1",
        "symbol": "PRSS1",
        "hgnc": "HGNC:9475",
        "name": "serine protease 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prss1"
      },
      {
        "slug": "prss2",
        "symbol": "PRSS2",
        "hgnc": "HGNC:9483",
        "name": "serine protease 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prss2"
      },
      {
        "slug": "slc2a10",
        "symbol": "SLC2A10",
        "hgnc": "HGNC:13444",
        "name": "solute carrier family 2 member 10",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc2a10"
      },
      {
        "slug": "spink1",
        "symbol": "SPINK1",
        "hgnc": "HGNC:11244",
        "name": "serine peptidase inhibitor Kazal type 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/spink1"
      }
    ]
  }
}