{
  "url": "https://dantelabs.com/traits/abnormal-sacrum-morphology",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-sacrum-morphology",
    "id": "HP:0005107",
    "name": "Abnormal sacrum morphology",
    "definition": "An abnormality of the sacral bone.",
    "synonyms": [
      "Abnormality of the sacrum"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-the-vertebral-column",
        "name": "Abnormality of the vertebral column",
        "url": "https://dantelabs.com/traits/abnormality-of-the-vertebral-column"
      }
    ],
    "narrower": [
      {
        "slug": "abnormal-sacroiliac-joint-morphology",
        "name": "Abnormal sacroiliac joint morphology",
        "genes": 5,
        "url": "https://dantelabs.com/traits/abnormal-sacroiliac-joint-morphology"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-sacrum",
        "name": "Absent/small sacrum",
        "genes": 4,
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-sacrum"
      },
      {
        "slug": "sacrococcygeal-teratoma",
        "name": "Sacrococcygeal teratoma",
        "genes": 4,
        "url": "https://dantelabs.com/traits/sacrococcygeal-teratoma"
      },
      {
        "slug": "horizontal-sacrum",
        "name": "Horizontal sacrum",
        "genes": 3,
        "url": "https://dantelabs.com/traits/horizontal-sacrum"
      },
      {
        "slug": "dysplastic-sacrum",
        "name": "Absence of some of the sacral and coccygeal bones",
        "genes": 2,
        "url": "https://dantelabs.com/traits/dysplastic-sacrum"
      },
      {
        "slug": "sacrococcygeal-pilonidal-abnormality",
        "name": "Sacrococcygeal pilonidal abnormality",
        "genes": 1,
        "url": "https://dantelabs.com/traits/sacrococcygeal-pilonidal-abnormality"
      },
      {
        "slug": "abnormal-ossification-of-the-sacrum",
        "name": "Abnormal ossification of the sacrum",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-ossification-of-the-sacrum"
      },
      {
        "slug": "sacral-meningocele",
        "name": "Sacral meningocele",
        "genes": 0,
        "url": "https://dantelabs.com/traits/sacral-meningocele"
      },
      {
        "slug": "sacral-segmentation-defect",
        "name": "Sacral segmentation defect",
        "genes": 0,
        "url": "https://dantelabs.com/traits/sacral-segmentation-defect"
      }
    ],
    "genes": [
      {
        "slug": "fgf20",
        "symbol": "FGF20",
        "hgnc": "HGNC:3677",
        "name": "fibroblast growth factor 20",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgf20"
      },
      {
        "slug": "gfra1",
        "symbol": "GFRA1",
        "hgnc": "HGNC:4243",
        "name": "GDNF family receptor alpha 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gfra1"
      },
      {
        "slug": "greb1l",
        "symbol": "GREB1L",
        "hgnc": "HGNC:31042",
        "name": "GREB1 like retinoic acid receptor coactivator",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/greb1l"
      },
      {
        "slug": "itga8",
        "symbol": "ITGA8",
        "hgnc": "HGNC:6144",
        "name": "integrin subunit alpha 8",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itga8"
      },
      {
        "slug": "ret",
        "symbol": "RET",
        "hgnc": "HGNC:9967",
        "name": "ret proto-oncogene",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ret"
      },
      {
        "slug": "runx2",
        "symbol": "RUNX2",
        "hgnc": "HGNC:10472",
        "name": "RUNX family transcription factor 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/runx2"
      },
      {
        "slug": "wnt9b",
        "symbol": "WNT9B",
        "hgnc": "HGNC:12779",
        "name": "Wnt family member 9B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wnt9b"
      },
      {
        "slug": "fgfr2",
        "symbol": "FGFR2",
        "hgnc": "HGNC:3689",
        "name": "fibroblast growth factor receptor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfr2"
      },
      {
        "slug": "fgfr3",
        "symbol": "FGFR3",
        "hgnc": "HGNC:3690",
        "name": "fibroblast growth factor receptor 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfr3"
      },
      {
        "slug": "gdf3",
        "symbol": "GDF3",
        "hgnc": "HGNC:4218",
        "name": "growth differentiation factor 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gdf3"
      },
      {
        "slug": "gdf6",
        "symbol": "GDF6",
        "hgnc": "HGNC:4221",
        "name": "growth differentiation factor 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gdf6"
      },
      {
        "slug": "hoxd13",
        "symbol": "HOXD13",
        "hgnc": "HGNC:5136",
        "name": "homeobox D13",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hoxd13"
      },
      {
        "slug": "meox1",
        "symbol": "MEOX1",
        "hgnc": "HGNC:7013",
        "name": "mesenchyme homeobox 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/meox1"
      },
      {
        "slug": "notch3",
        "symbol": "NOTCH3",
        "hgnc": "HGNC:7883",
        "name": "notch receptor 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/notch3"
      },
      {
        "slug": "pdgfrb",
        "symbol": "PDGFRB",
        "hgnc": "HGNC:8804",
        "name": "platelet derived growth factor receptor beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pdgfrb"
      },
      {
        "slug": "srd5a3",
        "symbol": "SRD5A3",
        "hgnc": "HGNC:25812",
        "name": "steroid 5 alpha-reductase 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/srd5a3"
      },
      {
        "slug": "tbx6",
        "symbol": "TBX6",
        "hgnc": "HGNC:11605",
        "name": "T-box transcription factor 6",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx6"
      }
    ]
  }
}