{
  "url": "https://dantelabs.com/traits/abnormal-renal-physiology",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "abnormal-renal-physiology",
    "id": "HP:0012211",
    "name": "Abnormal kidney function",
    "label": "Abnormal renal physiology",
    "definition": "An abnormal functionality of the kidney.",
    "synonyms": [
      "Kidney function issue",
      "Abnormal renal function",
      "Abnormality of renal physiology",
      "Renal functional abnormality"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-the-kidney",
        "name": "Abnormality of the kidney",
        "url": "https://dantelabs.com/traits/abnormality-of-the-kidney"
      },
      {
        "slug": "abnormality-of-the-urinary-system-physiology",
        "name": "Abnormality of the urinary system physiology",
        "url": "https://dantelabs.com/traits/abnormality-of-the-urinary-system-physiology"
      }
    ],
    "narrower": [
      {
        "slug": "renal-insufficiency",
        "name": "Renal failure",
        "genes": 312,
        "url": "https://dantelabs.com/traits/renal-insufficiency"
      },
      {
        "slug": "hematuria",
        "name": "Blood in urine",
        "genes": 163,
        "url": "https://dantelabs.com/traits/hematuria"
      },
      {
        "slug": "nephrotic-syndrome",
        "name": "Nephrotic syndrome",
        "genes": 125,
        "url": "https://dantelabs.com/traits/nephrotic-syndrome"
      },
      {
        "slug": "nephropathy",
        "name": "Kidney damage",
        "genes": 103,
        "url": "https://dantelabs.com/traits/nephropathy"
      },
      {
        "slug": "renal-tubular-dysfunction",
        "name": "Abnormal function of filtrating structures in kidney",
        "genes": 34,
        "url": "https://dantelabs.com/traits/renal-tubular-dysfunction"
      },
      {
        "slug": "renovascular-hypertension",
        "name": "Renovascular hypertension",
        "genes": 28,
        "url": "https://dantelabs.com/traits/renovascular-hypertension"
      },
      {
        "slug": "nephritis",
        "name": "Kidney inflammation",
        "genes": 24,
        "url": "https://dantelabs.com/traits/nephritis"
      },
      {
        "slug": "hemolytic-uremic-syndrome",
        "name": "Hemolytic-uremic syndrome",
        "genes": 17,
        "url": "https://dantelabs.com/traits/hemolytic-uremic-syndrome"
      },
      {
        "slug": "abnormality-of-renal-excretion",
        "name": "Abnormality of renal excretion",
        "genes": 2,
        "url": "https://dantelabs.com/traits/abnormality-of-renal-excretion"
      },
      {
        "slug": "impaired-urinary-acidification",
        "name": "Impaired urinary acidification",
        "genes": 1,
        "url": "https://dantelabs.com/traits/impaired-urinary-acidification"
      },
      {
        "slug": "isothenuria",
        "name": "Isothenuria",
        "genes": 1,
        "url": "https://dantelabs.com/traits/isothenuria"
      },
      {
        "slug": "abnormal-glomerular-filtration-rate",
        "name": "Abnormal glomerular filtration rate",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-glomerular-filtration-rate"
      }
    ],
    "genes": [
      {
        "slug": "hoga1",
        "symbol": "HOGA1",
        "hgnc": "HGNC:25155",
        "name": "4-hydroxy-2-oxoglutarate aldolase 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hoga1"
      },
      {
        "slug": "myo5b",
        "symbol": "MYO5B",
        "hgnc": "HGNC:7603",
        "name": "myosin VB",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myo5b"
      },
      {
        "slug": "prf1",
        "symbol": "PRF1",
        "hgnc": "HGNC:9360",
        "name": "perforin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prf1"
      },
      {
        "slug": "slc22a12",
        "symbol": "SLC22A12",
        "hgnc": "HGNC:17989",
        "name": "solute carrier family 22 member 12",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc22a12"
      },
      {
        "slug": "slc2a9",
        "symbol": "SLC2A9",
        "hgnc": "HGNC:13446",
        "name": "solute carrier family 2 member 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc2a9"
      },
      {
        "slug": "stx11",
        "symbol": "STX11",
        "hgnc": "HGNC:11429",
        "name": "syntaxin 11",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stx11"
      },
      {
        "slug": "stx3",
        "symbol": "STX3",
        "hgnc": "HGNC:11438",
        "name": "syntaxin 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stx3"
      },
      {
        "slug": "stxbp2",
        "symbol": "STXBP2",
        "hgnc": "HGNC:11445",
        "name": "syntaxin binding protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/stxbp2"
      },
      {
        "slug": "ttr",
        "symbol": "TTR",
        "hgnc": "HGNC:12405",
        "name": "transthyretin",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ttr"
      },
      {
        "slug": "unc13d",
        "symbol": "UNC13D",
        "hgnc": "HGNC:23147",
        "name": "unc-13 homolog D",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/unc13d"
      },
      {
        "slug": "cdk4",
        "symbol": "CDK4",
        "hgnc": "HGNC:1773",
        "name": "cyclin dependent kinase 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdk4"
      },
      {
        "slug": "hmga2",
        "symbol": "HMGA2",
        "hgnc": "HGNC:5009",
        "name": "high mobility group AT-hook 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hmga2"
      },
      {
        "slug": "mdm2",
        "symbol": "MDM2",
        "hgnc": "HGNC:6973",
        "name": "MDM2 proto-oncogene",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mdm2"
      },
      {
        "slug": "pex7",
        "symbol": "PEX7",
        "hgnc": "HGNC:8860",
        "name": "peroxisomal biogenesis factor 7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pex7"
      },
      {
        "slug": "phyh",
        "symbol": "PHYH",
        "hgnc": "HGNC:8940",
        "name": "phytanoyl-CoA 2-hydroxylase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/phyh"
      },
      {
        "slug": "adamts13",
        "symbol": "ADAMTS13",
        "hgnc": "HGNC:1366",
        "name": "ADAM metallopeptidase with thrombospondin type 1 motif 13",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adamts13"
      },
      {
        "slug": "elp1",
        "symbol": "ELP1",
        "hgnc": "HGNC:5959",
        "name": "elongator acetyltransferase complex subunit 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/elp1"
      }
    ]
  }
}