{
  "url": "https://dantelabs.com/traits/abnormal-clavicle-morphology",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "abnormal-clavicle-morphology",
    "id": "HP:0000889",
    "name": "Abnormal collarbone",
    "label": "Abnormal clavicle morphology",
    "definition": "Any abnormality of the clavicles (collar bones).",
    "synonyms": [
      "Abnormal clavicles",
      "Abnormality of the clavicle"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-thorax-morphology",
        "name": "Abnormality of the chest",
        "url": "https://dantelabs.com/traits/abnormal-thorax-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "lateral-clavicle-hook",
        "name": "Hook-shaped collarbone",
        "genes": 16,
        "url": "https://dantelabs.com/traits/lateral-clavicle-hook"
      },
      {
        "slug": "long-clavicle",
        "name": "Long collarbone",
        "genes": 15,
        "url": "https://dantelabs.com/traits/long-clavicle"
      },
      {
        "slug": "broad-clavicle",
        "name": "Broad collarbone",
        "genes": 11,
        "url": "https://dantelabs.com/traits/broad-clavicle"
      },
      {
        "slug": "straight-clavicle",
        "name": "Straight collarbone",
        "genes": 8,
        "url": "https://dantelabs.com/traits/straight-clavicle"
      },
      {
        "slug": "thin-clavicle",
        "name": "Thin collarbone",
        "genes": 5,
        "url": "https://dantelabs.com/traits/thin-clavicle"
      },
      {
        "slug": "aplasia-hypoplasia-of-the-clavicles",
        "name": "Absent/small collarbone",
        "genes": 4,
        "url": "https://dantelabs.com/traits/aplasia-hypoplasia-of-the-clavicles"
      },
      {
        "slug": "progressive-clavicular-acroosteolysis",
        "name": "Progressive clavicular acroosteolysis",
        "genes": 3,
        "url": "https://dantelabs.com/traits/progressive-clavicular-acroosteolysis"
      },
      {
        "slug": "clavicular-pseudarthrosis",
        "name": "Clavicular pseudarthrosis",
        "genes": 2,
        "url": "https://dantelabs.com/traits/clavicular-pseudarthrosis"
      },
      {
        "slug": "clavicular-sclerosis",
        "name": "Increased bone density in collarbone",
        "genes": 2,
        "url": "https://dantelabs.com/traits/clavicular-sclerosis"
      },
      {
        "slug": "medial-widening-of-clavicle",
        "name": "Medial widening of clavicle",
        "genes": 1,
        "url": "https://dantelabs.com/traits/medial-widening-of-clavicle"
      },
      {
        "slug": "thickened-cortex-of-the-clavicle",
        "name": "Thickened cortex of the clavicle",
        "genes": 1,
        "url": "https://dantelabs.com/traits/thickened-cortex-of-the-clavicle"
      },
      {
        "slug": "undulate-clavicle",
        "name": "Wavy collarbone",
        "genes": 1,
        "url": "https://dantelabs.com/traits/undulate-clavicle"
      }
    ],
    "genes": [
      {
        "slug": "lrp5",
        "symbol": "LRP5",
        "hgnc": "HGNC:6697",
        "name": "LDL receptor related protein 5",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrp5"
      },
      {
        "slug": "rnu12",
        "symbol": "RNU12",
        "hgnc": "HGNC:19380",
        "name": "RNA, U12 small nuclear",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu12"
      },
      {
        "slug": "slc26a2",
        "symbol": "SLC26A2",
        "hgnc": "HGNC:10994",
        "name": "solute carrier family 26 member 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slc26a2"
      },
      {
        "slug": "sost",
        "symbol": "SOST",
        "hgnc": "HGNC:13771",
        "name": "sclerostin",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sost"
      },
      {
        "slug": "tbx5",
        "symbol": "TBX5",
        "hgnc": "HGNC:11604",
        "name": "T-box transcription factor 5",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx5"
      },
      {
        "slug": "tnfrsf11a",
        "symbol": "TNFRSF11A",
        "hgnc": "HGNC:11908",
        "name": "TNF receptor superfamily member 11a",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfrsf11a"
      },
      {
        "slug": "tnfrsf11b",
        "symbol": "TNFRSF11B",
        "hgnc": "HGNC:11909",
        "name": "TNF receptor superfamily member 11b",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfrsf11b"
      },
      {
        "slug": "antxr1",
        "symbol": "ANTXR1",
        "hgnc": "HGNC:21014",
        "name": "ANTXR cell adhesion molecule 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/antxr1"
      },
      {
        "slug": "cep120",
        "symbol": "CEP120",
        "hgnc": "HGNC:26690",
        "name": "centrosomal protein 120",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cep120"
      },
      {
        "slug": "dync2h1",
        "symbol": "DYNC2H1",
        "hgnc": "HGNC:2962",
        "name": "dynein cytoplasmic 2 heavy chain 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dync2h1"
      },
      {
        "slug": "dync2i1",
        "symbol": "DYNC2I1",
        "hgnc": "HGNC:21862",
        "name": "dynein 2 intermediate chain 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dync2i1"
      },
      {
        "slug": "dync2i2",
        "symbol": "DYNC2I2",
        "hgnc": "HGNC:28296",
        "name": "dynein 2 intermediate chain 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dync2i2"
      },
      {
        "slug": "dync2li1",
        "symbol": "DYNC2LI1",
        "hgnc": "HGNC:24595",
        "name": "dynein cytoplasmic 2 light intermediate chain 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dync2li1"
      },
      {
        "slug": "efnb1",
        "symbol": "EFNB1",
        "hgnc": "HGNC:3226",
        "name": "ephrin B1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/efnb1"
      },
      {
        "slug": "fgfr1",
        "symbol": "FGFR1",
        "hgnc": "HGNC:3688",
        "name": "fibroblast growth factor receptor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfr1"
      },
      {
        "slug": "fgfr3",
        "symbol": "FGFR3",
        "hgnc": "HGNC:3690",
        "name": "fibroblast growth factor receptor 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfr3"
      },
      {
        "slug": "idua",
        "symbol": "IDUA",
        "hgnc": "HGNC:5391",
        "name": "alpha-L-iduronidase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/idua"
      },
      {
        "slug": "ift140",
        "symbol": "IFT140",
        "hgnc": "HGNC:29077",
        "name": "intraflagellar transport 140",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift140"
      },
      {
        "slug": "ift172",
        "symbol": "IFT172",
        "hgnc": "HGNC:30391",
        "name": "intraflagellar transport 172",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift172"
      },
      {
        "slug": "ift80",
        "symbol": "IFT80",
        "hgnc": "HGNC:29262",
        "name": "intraflagellar transport 80",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift80"
      },
      {
        "slug": "kiaa0753",
        "symbol": "KIAA0753",
        "hgnc": "HGNC:29110",
        "name": "KIAA0753",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kiaa0753"
      },
      {
        "slug": "ttc21b",
        "symbol": "TTC21B",
        "hgnc": "HGNC:25660",
        "name": "tetratricopeptide repeat domain 21B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ttc21b"
      },
      {
        "slug": "wdr19",
        "symbol": "WDR19",
        "hgnc": "HGNC:18340",
        "name": "WD repeat domain 19",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr19"
      },
      {
        "slug": "bcor",
        "symbol": "BCOR",
        "hgnc": "HGNC:20893",
        "name": "BCL6 corepressor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcor"
      },
      {
        "slug": "ctsk",
        "symbol": "CTSK",
        "hgnc": "HGNC:2536",
        "name": "cathepsin K",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctsk"
      },
      {
        "slug": "fkbp10",
        "symbol": "FKBP10",
        "hgnc": "HGNC:18169",
        "name": "FKBP prolyl isomerase 10",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fkbp10"
      },
      {
        "slug": "gja1",
        "symbol": "GJA1",
        "hgnc": "HGNC:4274",
        "name": "gap junction protein alpha 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gja1"
      },
      {
        "slug": "gli3",
        "symbol": "GLI3",
        "hgnc": "HGNC:4319",
        "name": "GLI family zinc finger 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gli3"
      },
      {
        "slug": "kif7",
        "symbol": "KIF7",
        "hgnc": "HGNC:30497",
        "name": "kinesin family member 7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kif7"
      },
      {
        "slug": "naa10",
        "symbol": "NAA10",
        "hgnc": "HGNC:18704",
        "name": "N-alpha-acetyltransferase 10, NatA catalytic subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/naa10"
      },
      {
        "slug": "setbp1",
        "symbol": "SETBP1",
        "hgnc": "HGNC:15573",
        "name": "SET binding protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/setbp1"
      },
      {
        "slug": "tbx3",
        "symbol": "TBX3",
        "hgnc": "HGNC:11602",
        "name": "T-box transcription factor 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx3"
      }
    ]
  }
}