{
  "url": "https://dantelabs.com/traits/abnormal-cd4-cd8-ratio",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-cd4-cd8-ratio",
    "id": "HP:0031394",
    "name": "Abnormal CD4:CD8 ratio",
    "definition": "Any abnormality in the relative amount of CD4+ and CD8+ T lymphocytes.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-t-cell-subset-number",
        "name": "Abnormal T cell subset number",
        "url": "https://dantelabs.com/traits/abnormal-t-cell-subset-number"
      }
    ],
    "narrower": [
      {
        "slug": "inverted-cd4-cd8-ratio",
        "name": "Inverted CD4:CD8 ratio",
        "genes": 15,
        "url": "https://dantelabs.com/traits/inverted-cd4-cd8-ratio"
      },
      {
        "slug": "increased-cd4-cd8-ratio",
        "name": "Increased CD4:CD8 ratio",
        "genes": 10,
        "url": "https://dantelabs.com/traits/increased-cd4-cd8-ratio"
      }
    ],
    "genes": [
      {
        "slug": "rasgrp1",
        "symbol": "RASGRP1",
        "hgnc": "HGNC:9878",
        "name": "RAS guanyl releasing protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rasgrp1"
      },
      {
        "slug": "wdr1",
        "symbol": "WDR1",
        "hgnc": "HGNC:12754",
        "name": "WD repeat domain 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr1"
      },
      {
        "slug": "ciita",
        "symbol": "CIITA",
        "hgnc": "HGNC:7067",
        "name": "class II major histocompatibility complex transactivator",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ciita"
      },
      {
        "slug": "pgm3",
        "symbol": "PGM3",
        "hgnc": "HGNC:8907",
        "name": "phosphoglucomutase 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pgm3"
      },
      {
        "slug": "rfx5",
        "symbol": "RFX5",
        "hgnc": "HGNC:9986",
        "name": "regulatory factor X5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rfx5"
      },
      {
        "slug": "rfxank",
        "symbol": "RFXANK",
        "hgnc": "HGNC:9987",
        "name": "regulatory factor X associated ankyrin containing protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rfxank"
      },
      {
        "slug": "rfxap",
        "symbol": "RFXAP",
        "hgnc": "HGNC:9988",
        "name": "regulatory factor X associated protein",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rfxap"
      }
    ]
  }
}