{
  "url": "https://dantelabs.com/traits/abnormal-cartilage-morphology",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "abnormal-cartilage-morphology",
    "id": "HP:0002763",
    "name": "Abnormal shape of cartilage",
    "label": "Abnormal cartilage morphology",
    "definition": "Any morphological abnormality of cartilage.",
    "synonyms": [
      "Abnormality of cartilage morphology"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-musculoskeletal-system",
        "name": "Abnormality of the musculoskeletal system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-musculoskeletal-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-skeletal-morphology",
        "name": "Abnormally shaped skeletal",
        "url": "https://dantelabs.com/traits/abnormal-skeletal-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "multiple-enchondromatosis",
        "name": "Multiple enchondromatosis",
        "genes": 10,
        "url": "https://dantelabs.com/traits/multiple-enchondromatosis"
      },
      {
        "slug": "calcification-of-cartilage",
        "name": "Calcification of cartilage",
        "genes": 5,
        "url": "https://dantelabs.com/traits/calcification-of-cartilage"
      },
      {
        "slug": "cartilage-destruction",
        "name": "Cartilage destruction",
        "genes": 4,
        "url": "https://dantelabs.com/traits/cartilage-destruction"
      },
      {
        "slug": "abnormal-cartilage-collagen",
        "name": "Abnormal cartilage collagen",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormal-cartilage-collagen"
      },
      {
        "slug": "abnormal-cricoid-cartilage-morphology",
        "name": "Abnormal cricoid cartilage morphology",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormal-cricoid-cartilage-morphology"
      },
      {
        "slug": "abnormal-chondrocyte-morphology",
        "name": "Abnormal chondrocyte morphology",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-chondrocyte-morphology"
      },
      {
        "slug": "abnormal-external-ear-cartilage-morphology",
        "name": "Abnormal external ear cartilage morphology",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormal-external-ear-cartilage-morphology"
      },
      {
        "slug": "abnormality-nasal-septum-cartilage-morphology",
        "name": "Abnormality of cartilage of nasal septum",
        "genes": 0,
        "url": "https://dantelabs.com/traits/abnormality-nasal-septum-cartilage-morphology"
      },
      {
        "slug": "chondritis",
        "name": "Cartilage inflammation",
        "genes": 0,
        "url": "https://dantelabs.com/traits/chondritis"
      }
    ],
    "genes": [
      {
        "slug": "idh1",
        "symbol": "IDH1",
        "hgnc": "HGNC:5382",
        "name": "isocitrate dehydrogenase (NADP(+)) 1",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/idh1"
      },
      {
        "slug": "idh2",
        "symbol": "IDH2",
        "hgnc": "HGNC:5383",
        "name": "isocitrate dehydrogenase (NADP(+)) 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/idh2"
      },
      {
        "slug": "pth1r",
        "symbol": "PTH1R",
        "hgnc": "HGNC:9608",
        "name": "parathyroid hormone 1 receptor",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pth1r"
      },
      {
        "slug": "ext1",
        "symbol": "EXT1",
        "hgnc": "HGNC:3512",
        "name": "exostosin glycosyltransferase 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ext1"
      },
      {
        "slug": "ext2",
        "symbol": "EXT2",
        "hgnc": "HGNC:3513",
        "name": "exostosin glycosyltransferase 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ext2"
      },
      {
        "slug": "trappc2",
        "symbol": "TRAPPC2",
        "hgnc": "HGNC:23068",
        "name": "trafficking protein particle complex subunit 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trappc2"
      },
      {
        "slug": "fgfr1",
        "symbol": "FGFR1",
        "hgnc": "HGNC:3688",
        "name": "fibroblast growth factor receptor 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfr1"
      },
      {
        "slug": "kras",
        "symbol": "KRAS",
        "hgnc": "HGNC:6407",
        "name": "KRas proto-oncogene, GTPase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kras"
      }
    ]
  }
}