{
  "url": "https://dantelabs.com/traits/abnormal-bone-marrow-cell-morphology",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "abnormal-bone-marrow-cell-morphology",
    "id": "HP:0005561",
    "name": "Bone marrow disease",
    "label": "Abnormal bone marrow cell morphology",
    "definition": "An anomaly of the form or number of cells in the bone marrow.",
    "synonyms": [
      "Abnormality of bone marrow cell morphology",
      "Anomaly of the bone marrow cells"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      }
    ],
    "narrower": [
      {
        "slug": "abnormal-megakaryocyte-morphology",
        "name": "Abnormal megakaryocyte morphology",
        "genes": 11,
        "url": "https://dantelabs.com/traits/abnormal-megakaryocyte-morphology"
      },
      {
        "slug": "abnormality-of-multiple-cell-lineages-in-the-bone-marrow",
        "name": "Abnormality of multiple cell lineages in the bone marrow",
        "genes": 7,
        "url": "https://dantelabs.com/traits/abnormality-of-multiple-cell-lineages-in-the-bone-marrow"
      },
      {
        "slug": "bone-marrow-maturation-arrest",
        "name": "Bone marrow maturation arrest",
        "genes": 6,
        "url": "https://dantelabs.com/traits/bone-marrow-maturation-arrest"
      },
      {
        "slug": "abnormal-erythroid-lineage-cell-morphology",
        "name": "Abnormal erythroid lineage cell morphology",
        "genes": 2,
        "url": "https://dantelabs.com/traits/abnormal-erythroid-lineage-cell-morphology"
      },
      {
        "slug": "abnormal-granulocytopoietic-cell-morphology",
        "name": "Abnormal granulocytopoietic cell morphology",
        "genes": 2,
        "url": "https://dantelabs.com/traits/abnormal-granulocytopoietic-cell-morphology"
      },
      {
        "slug": "lymphoid-hyperplasia",
        "name": "Lymphoid hyperplasia",
        "genes": 2,
        "url": "https://dantelabs.com/traits/lymphoid-hyperplasia"
      },
      {
        "slug": "abnormality-of-bone-marrow-stromal-cells",
        "name": "Abnormality of bone marrow stromal cells",
        "genes": 1,
        "url": "https://dantelabs.com/traits/abnormality-of-bone-marrow-stromal-cells"
      },
      {
        "slug": "bone-marrow-cystine-accumulation",
        "name": "Bone marrow cystine accumulation",
        "genes": 1,
        "url": "https://dantelabs.com/traits/bone-marrow-cystine-accumulation"
      },
      {
        "slug": "increased-bone-marrow-iron",
        "name": "Increased bone marrow iron",
        "genes": 1,
        "url": "https://dantelabs.com/traits/increased-bone-marrow-iron"
      }
    ],
    "genes": [
      {
        "slug": "calr",
        "symbol": "CALR",
        "hgnc": "HGNC:1455",
        "name": "calreticulin",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/calr"
      },
      {
        "slug": "jak2",
        "symbol": "JAK2",
        "hgnc": "HGNC:6192",
        "name": "Janus kinase 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/jak2"
      },
      {
        "slug": "lpin2",
        "symbol": "LPIN2",
        "hgnc": "HGNC:14450",
        "name": "lipin 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lpin2"
      },
      {
        "slug": "mpl",
        "symbol": "MPL",
        "hgnc": "HGNC:7217",
        "name": "MPL proto-oncogene, thrombopoietin receptor",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mpl"
      },
      {
        "slug": "sh2b3",
        "symbol": "SH2B3",
        "hgnc": "HGNC:29605",
        "name": "SH2B adaptor protein 3",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sh2b3"
      },
      {
        "slug": "tet2",
        "symbol": "TET2",
        "hgnc": "HGNC:25941",
        "name": "tet methylcytosine dioxygenase 2",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tet2"
      },
      {
        "slug": "tp53",
        "symbol": "TP53",
        "hgnc": "HGNC:11998",
        "name": "tumor protein p53",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tp53"
      },
      {
        "slug": "atm",
        "symbol": "ATM",
        "hgnc": "HGNC:795",
        "name": "ATM serine/threonine kinase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atm"
      },
      {
        "slug": "ccnd1",
        "symbol": "CCND1",
        "hgnc": "HGNC:1582",
        "name": "cyclin D1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccnd1"
      },
      {
        "slug": "igh",
        "symbol": "IGH",
        "hgnc": "HGNC:5477",
        "name": "immunoglobulin heavy locus",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/igh"
      },
      {
        "slug": "lig4",
        "symbol": "LIG4",
        "hgnc": "HGNC:6601",
        "name": "DNA ligase 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lig4"
      },
      {
        "slug": "myc",
        "symbol": "MYC",
        "hgnc": "HGNC:7553",
        "name": "MYC proto-oncogene, bHLH transcription factor",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/myc"
      },
      {
        "slug": "cd28",
        "symbol": "CD28",
        "hgnc": "HGNC:1653",
        "name": "CD28 molecule",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cd28"
      },
      {
        "slug": "ctla4",
        "symbol": "CTLA4",
        "hgnc": "HGNC:2505",
        "name": "cytotoxic T-lymphocyte associated protein 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ctla4"
      },
      {
        "slug": "dync2li1",
        "symbol": "DYNC2LI1",
        "hgnc": "HGNC:24595",
        "name": "dynein cytoplasmic 2 light intermediate chain 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dync2li1"
      },
      {
        "slug": "evc",
        "symbol": "EVC",
        "hgnc": "HGNC:3497",
        "name": "EvC ciliary complex subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/evc"
      },
      {
        "slug": "evc2",
        "symbol": "EVC2",
        "hgnc": "HGNC:19747",
        "name": "EvC ciliary complex subunit 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/evc2"
      },
      {
        "slug": "gli1",
        "symbol": "GLI1",
        "hgnc": "HGNC:4317",
        "name": "GLI family zinc finger 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gli1"
      },
      {
        "slug": "hpgd",
        "symbol": "HPGD",
        "hgnc": "HGNC:5154",
        "name": "15-hydroxyprostaglandin dehydrogenase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hpgd"
      },
      {
        "slug": "prkaca",
        "symbol": "PRKACA",
        "hgnc": "HGNC:9380",
        "name": "protein kinase cAMP-activated catalytic subunit alpha",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkaca"
      },
      {
        "slug": "prkacb",
        "symbol": "PRKACB",
        "hgnc": "HGNC:9381",
        "name": "protein kinase cAMP-activated catalytic subunit beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkacb"
      },
      {
        "slug": "slco2a1",
        "symbol": "SLCO2A1",
        "hgnc": "HGNC:10955",
        "name": "solute carrier organic anion transporter family member 2A1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/slco2a1"
      },
      {
        "slug": "tnfrsf1b",
        "symbol": "TNFRSF1B",
        "hgnc": "HGNC:11917",
        "name": "TNF receptor superfamily member 1B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tnfrsf1b"
      },
      {
        "slug": "cxcr4",
        "symbol": "CXCR4",
        "hgnc": "HGNC:2561",
        "name": "C-X-C motif chemokine receptor 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cxcr4"
      }
    ]
  }
}