{
  "url": "https://dantelabs.com/cs/genes/slc11a2",
  "gene": {
    "slug": "slc11a2",
    "symbol": "SLC11A2",
    "name": "solute carrier family 11 member 2",
    "hgnc": "HGNC:10908",
    "summary": null,
    "location": "12q13.12",
    "locusType": "gene with protein product",
    "aliases": [
      "DCT1",
      "DMT1",
      "DMT-1",
      "FLJ37416"
    ],
    "previousSymbols": [
      "NRAMP2"
    ],
    "ensemblId": "ENSG00000110911",
    "entrezId": 4891,
    "omim": [
      "600523"
    ],
    "uniprot": [
      "P49281"
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    "model": {
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      "release": "v1.5",
      "chrom": "12",
      "start": 50985992,
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      "ensemblTranscript": "ENST00000262052.9",
      "refseqTranscript": "NM_000617.3",
      "ensemblProtein": "ENSP00000262052.5",
      "refseqProtein": "NP_000608.1",
      "exons": [
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        {
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      "cds": {
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        "end": 51010728
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "12",
      "start": 51373184,
      "end": 51422349,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 50506188,
      "end": 51506187,
      "genes": [
        {
          "symbol": "DIP2B",
          "ensemblId": "ENSG00000066084",
          "biotype": "protein_coding",
          "start": 50504962,
          "end": 50748657,
          "strand": "+",
          "slug": "dip2b"
        },
        {
          "symbol": "ATF1",
          "ensemblId": "ENSG00000123268",
          "biotype": "protein_coding",
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          "strand": "+",
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        },
        {
          "symbol": "TMPRSS12",
          "ensemblId": "ENSG00000186452",
          "biotype": "protein_coding",
          "start": 50842920,
          "end": 50887884,
          "strand": "+",
          "slug": "tmprss12"
        },
        {
          "symbol": "TMT1A",
          "ensemblId": "ENSG00000185432",
          "biotype": "protein_coding",
          "start": 50923472,
          "end": 50932510,
          "strand": "+",
          "slug": "tmt1a"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000289695",
          "biotype": "protein_coding",
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          "end": 50970700,
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        },
        {
          "symbol": "HIGD1C",
          "ensemblId": "ENSG00000214511",
          "biotype": "protein_coding",
          "start": 50952538,
          "end": 50970860,
          "strand": "+",
          "slug": "higd1c"
        },
        {
          "symbol": "LETMD1",
          "ensemblId": "ENSG00000050426",
          "biotype": "protein_coding",
          "start": 51047962,
          "end": 51068961,
          "strand": "+",
          "slug": "letmd1"
        },
        {
          "symbol": "CSRNP2",
          "ensemblId": "ENSG00000110925",
          "biotype": "protein_coding",
          "start": 51061205,
          "end": 51083664,
          "strand": "-",
          "slug": "csrnp2"
        },
        {
          "symbol": "TFCP2",
          "ensemblId": "ENSG00000135457",
          "biotype": "protein_coding",
          "start": 51093656,
          "end": 51173137,
          "strand": "-",
          "slug": "tfcp2"
        },
        {
          "symbol": "POU6F1",
          "ensemblId": "ENSG00000184271",
          "biotype": "protein_coding",
          "start": 51186936,
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          "strand": "-",
          "slug": "pou6f1"
        },
        {
          "symbol": "DAZAP2",
          "ensemblId": "ENSG00000183283",
          "biotype": "protein_coding",
          "start": 51238724,
          "end": 51272164,
          "strand": "+",
          "slug": "dazap2"
        },
        {
          "symbol": "SMAGP",
          "ensemblId": "ENSG00000170545",
          "biotype": "protein_coding",
          "start": 51244558,
          "end": 51270517,
          "strand": "-",
          "slug": "smagp"
        },
        {
          "symbol": "BIN2",
          "ensemblId": "ENSG00000110934",
          "biotype": "protein_coding",
          "start": 51281038,
          "end": 51324668,
          "strand": "-",
          "slug": "bin2"
        },
        {
          "symbol": "CELA1",
          "ensemblId": "ENSG00000139610",
          "biotype": "protein_coding",
          "start": 51328442,
          "end": 51346804,
          "strand": "-",
          "slug": "cela1"
        },
        {
          "symbol": "GALNT6",
          "ensemblId": "ENSG00000139629",
          "biotype": "protein_coding",
          "start": 51351247,
          "end": 51392867,
          "strand": "-",
          "slug": "galnt6"
        },
        {
          "symbol": "SLC4A8",
          "ensemblId": "ENSG00000050438",
          "biotype": "protein_coding",
          "start": 51391317,
          "end": 51515763,
          "strand": "+",
          "slug": "slc4a8"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "inherited-iron-metabolism-disorders",
        "name": "Inherited Iron Metabolism Disorders",
        "diseases": [
          {
            "mondoId": "MONDO:0008787",
            "name": "Microcytic Anaemia with Liver Iron Overload (DMT1 Deficiency)",
            "genes": 1,
            "inheritance": "autosomal-recessive",
            "description": "Caused by changes in SLC11A2, which encodes the iron transporter DMT1, leading to anaemia from birth together with iron build-up in the liver.",
            "management": null,
            "evidence": {
              "gencc": [
                "ClinGen",
                "Genomics England PanelApp",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/cs/conditions/inherited-iron-metabolism-disorders"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "decreased-mean-corpuscular-volume",
        "name": "Decreased mean corpuscular volume",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-mean-corpuscular-volume"
      },
      {
        "slug": "elevated-circulating-iron-concentration",
        "name": "Elevated circulating iron concentration",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/elevated-circulating-iron-concentration"
      },
      {
        "slug": "erythroid-hyperplasia",
        "name": "Erythroid hyperplasia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/erythroid-hyperplasia"
      },
      {
        "slug": "hypochromia",
        "name": "Hypochromia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypochromia"
      },
      {
        "slug": "hypochromic-microcytic-anemia",
        "name": "Hypochromic microcytic anemia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "url": "https://dantelabs.com/traits/hypochromic-microcytic-anemia"
      },
      {
        "slug": "elevated-hepatic-iron-concentration",
        "name": "Increased iron concentration in liver",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/elevated-hepatic-iron-concentration"
      },
      {
        "slug": "anemia",
        "name": "Low number of red blood cells or hemoglobin",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/anemia"
      }
    ],
    "related": [],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}