{
  "url": "https://dantelabs.com/cs/genes/hand2",
  "gene": {
    "slug": "hand2",
    "symbol": "HAND2",
    "name": "heart and neural crest derivatives expressed 2",
    "hgnc": "HGNC:4808",
    "summary": null,
    "location": "4q34.1",
    "locusType": "gene with protein product",
    "aliases": [
      "dHand",
      "Thing2",
      "Hed",
      "bHLHa26"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000164107",
    "entrezId": 9464,
    "omim": [
      "602407"
    ],
    "uniprot": [
      "P61296"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "4",
      "start": 173526091,
      "end": 173530229,
      "strand": "-",
      "ensemblTranscript": "ENST00000359562.4",
      "refseqTranscript": "NM_021973.3",
      "ensemblProtein": "ENSP00000352565.4",
      "refseqProtein": "NP_068808.1",
      "exons": [
        {
          "start": 173526091,
          "end": 173527375
        },
        {
          "start": 173528735,
          "end": 173530229
        }
      ],
      "cds": {
        "start": 173527277,
        "end": 173529289
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "4",
      "start": 174446120,
      "end": 174451380,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 173028160,
      "end": 174028159,
      "genes": [
        {
          "symbol": "GALNTL6",
          "ensemblId": "ENSG00000174473",
          "biotype": "protein_coding",
          "start": 171812254,
          "end": 173041559,
          "strand": "+",
          "slug": "galntl6"
        },
        {
          "symbol": "GALNT7",
          "ensemblId": "ENSG00000109586",
          "biotype": "protein_coding",
          "start": 173168811,
          "end": 173324257,
          "strand": "+",
          "slug": "galnt7"
        },
        {
          "symbol": "HMGB2",
          "ensemblId": "ENSG00000164104",
          "biotype": "protein_coding",
          "start": 173331376,
          "end": 173335152,
          "strand": "-",
          "slug": "hmgb2"
        },
        {
          "symbol": "SAP30",
          "ensemblId": "ENSG00000164105",
          "biotype": "protein_coding",
          "start": 173369969,
          "end": 173380480,
          "strand": "+",
          "slug": "sap30"
        },
        {
          "symbol": "SCRG1",
          "ensemblId": "ENSG00000164106",
          "biotype": "protein_coding",
          "start": 173384701,
          "end": 173416521,
          "strand": "-",
          "slug": "scrg1"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "arrhythmia",
        "name": "Abnormal heart rate",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/arrhythmia"
      },
      {
        "slug": "congestive-heart-failure",
        "name": "Cardiac failure",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/congestive-heart-failure"
      },
      {
        "slug": "emg-abnormality",
        "name": "EMG abnormality",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/emg-abnormality"
      },
      {
        "slug": "exertional-dyspnea",
        "name": "Exertional breathlessness",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/exertional-dyspnea"
      },
      {
        "slug": "fatigue",
        "name": "Fatigue",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/fatigue"
      },
      {
        "slug": "edema",
        "name": "Fluid retention",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/edema"
      },
      {
        "slug": "left-ventricular-systolic-dysfunction",
        "name": "Left ventricular systolic dysfunction",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/left-ventricular-systolic-dysfunction"
      },
      {
        "slug": "lipoatrophy",
        "name": "Loss of fat tissue in localized area",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/lipoatrophy"
      },
      {
        "slug": "myopathy",
        "name": "Muscle tissue disease",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/myopathy"
      },
      {
        "slug": "orthopnea",
        "name": "Orthopnea",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/orthopnea"
      },
      {
        "slug": "sensorineural-hearing-impairment",
        "name": "Sensorineural hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/sensorineural-hearing-impairment"
      },
      {
        "slug": "dilated-cardiomyopathy",
        "name": "Stretched and thinned heart muscle",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/dilated-cardiomyopathy"
      },
      {
        "slug": "thromboembolic-stroke",
        "name": "Thromboembolic stroke",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/thromboembolic-stroke"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}