{
  "url": "https://dantelabs.com/cs/genes/ephx2",
  "gene": {
    "slug": "ephx2",
    "symbol": "EPHX2",
    "name": "epoxide hydrolase 2",
    "hgnc": "HGNC:3402",
    "summary": null,
    "location": "8p21.2-p21.1",
    "locusType": "gene with protein product",
    "aliases": [
      "ABHD20",
      "sEH"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000120915",
    "entrezId": 2053,
    "omim": [
      "132811"
    ],
    "uniprot": [
      "P34913"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "8",
      "start": 27491143,
      "end": 27545564,
      "strand": "+",
      "ensemblTranscript": "ENST00000521400.6",
      "refseqTranscript": "NM_001979.6",
      "ensemblProtein": "ENSP00000430269.1",
      "refseqProtein": "NP_001970.2",
      "exons": [
        {
          "start": 27491143,
          "end": 27491309
        },
        {
          "start": 27500926,
          "end": 27501010
        },
        {
          "start": 27503604,
          "end": 27503763
        },
        {
          "start": 27504956,
          "end": 27505146
        },
        {
          "start": 27506872,
          "end": 27506994
        },
        {
          "start": 27511836,
          "end": 27511910
        },
        {
          "start": 27515718,
          "end": 27515813
        },
        {
          "start": 27516320,
          "end": 27516398
        },
        {
          "start": 27518038,
          "end": 27518072
        },
        {
          "start": 27520883,
          "end": 27520909
        },
        {
          "start": 27522423,
          "end": 27522508
        },
        {
          "start": 27525362,
          "end": 27525473
        },
        {
          "start": 27536784,
          "end": 27536855
        },
        {
          "start": 27538659,
          "end": 27538692
        },
        {
          "start": 27540554,
          "end": 27540656
        },
        {
          "start": 27541473,
          "end": 27541542
        },
        {
          "start": 27543749,
          "end": 27543829
        },
        {
          "start": 27544186,
          "end": 27544244
        },
        {
          "start": 27544444,
          "end": 27545564
        }
      ],
      "cds": {
        "start": 27491209,
        "end": 27544522
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "8",
      "start": 27348296,
      "end": 27403081,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 27018354,
      "end": 28018353,
      "genes": [
        {
          "symbol": "STMN4",
          "ensemblId": "ENSG00000015592",
          "biotype": "protein_coding",
          "start": 27230877,
          "end": 27258475,
          "strand": "-",
          "slug": "stmn4"
        },
        {
          "symbol": "TRIM35",
          "ensemblId": "ENSG00000104228",
          "biotype": "protein_coding",
          "start": 27284884,
          "end": 27311289,
          "strand": "-",
          "slug": "trim35"
        },
        {
          "symbol": "PTK2B",
          "ensemblId": "ENSG00000120899",
          "biotype": "protein_coding",
          "start": 27311456,
          "end": 27459392,
          "strand": "+",
          "slug": "ptk2b"
        },
        {
          "symbol": "CHRNA2",
          "ensemblId": "ENSG00000120903",
          "biotype": "protein_coding",
          "start": 27459756,
          "end": 27479883,
          "strand": "-",
          "slug": "chrna2"
        },
        {
          "symbol": "CLU",
          "ensemblId": "ENSG00000120885",
          "biotype": "protein_coding",
          "start": 27596917,
          "end": 27635085,
          "strand": "-",
          "slug": "clu"
        },
        {
          "symbol": "SCARA3",
          "ensemblId": "ENSG00000168077",
          "biotype": "protein_coding",
          "start": 27633372,
          "end": 27698687,
          "strand": "+",
          "slug": "scara3"
        },
        {
          "symbol": "CCDC25",
          "ensemblId": "ENSG00000147419",
          "biotype": "protein_coding",
          "start": 27733316,
          "end": 27772655,
          "strand": "-",
          "slug": "ccdc25"
        },
        {
          "symbol": "ESCO2",
          "ensemblId": "ENSG00000171320",
          "biotype": "protein_coding",
          "start": 27771949,
          "end": 27812640,
          "strand": "+",
          "slug": "esco2"
        },
        {
          "symbol": "PBK",
          "ensemblId": "ENSG00000168078",
          "biotype": "protein_coding",
          "start": 27809532,
          "end": 27838082,
          "strand": "-",
          "slug": "pbk"
        },
        {
          "symbol": "SCARA5",
          "ensemblId": "ENSG00000168079",
          "biotype": "protein_coding",
          "start": 27869883,
          "end": 27992840,
          "strand": "-",
          "slug": "scara5"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "corneal-arcus",
        "name": "Corneal arcus",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "url": "https://dantelabs.com/traits/corneal-arcus"
      },
      {
        "slug": "xanthelasma",
        "name": "Fatty deposits in skin around the eyes",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-integument"
        ],
        "url": "https://dantelabs.com/traits/xanthelasma"
      },
      {
        "slug": "elevated-circulating-ldl-c-concentration",
        "name": "Increased circulating LDL level",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/elevated-circulating-ldl-c-concentration"
      },
      {
        "slug": "coronary-artery-atherosclerosis",
        "name": "Plaque build-up in arteries supplying blood to heart",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "url": "https://dantelabs.com/traits/coronary-artery-atherosclerosis"
      },
      {
        "slug": "tendon-xanthomatosis",
        "name": "Tendon xanthomatosis",
        "systems": [
          "abnormality-of-the-integument",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/tendon-xanthomatosis"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}