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            "genes": 11,
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            "description": "A genetic inborn error of metabolism characterized by the deficiency of one of the enzymes necessary for the urea cycle. It results in accumulation of ammonia in the body.",
            "management": "Nitrogen scavenger therapy (sodium benzoate, glycerol phenylbutyrate/Ravicti); protein-restricted diet with essential amino acid supplementation; emergency hyperammonemia protocols; liver transplantation (curative); mRNA therapy trials for OTC; carglumic acid for NAGS deficiency",
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        "url": "https://dantelabs.com/traits/ataxia"
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      {
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        "url": "https://dantelabs.com/traits/coma"
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      {
        "slug": "decreased-circulating-citrulline-concentration",
        "name": "Decreased circulating citrulline concentration",
        "systems": [
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        "url": "https://dantelabs.com/traits/decreased-circulating-citrulline-concentration"
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      {
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        "name": "Epilepsy",
        "systems": [
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        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/seizure"
      },
      {
        "slug": "episodic-ammonia-intoxication",
        "name": "Episodic ammonia intoxication",
        "systems": [
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        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/episodic-ammonia-intoxication"
      },
      {
        "slug": "failure-to-thrive",
        "name": "Faltering weight",
        "systems": [
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        "url": "https://dantelabs.com/traits/failure-to-thrive"
      },
      {
        "slug": "global-developmental-delay",
        "name": "Global developmental delay",
        "systems": [
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        ],
        "url": "https://dantelabs.com/traits/global-developmental-delay"
      },
      {
        "slug": "hyperammonemia",
        "name": "High blood ammonia levels",
        "systems": [
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        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hyperammonemia"
      },
      {
        "slug": "intellectual-disability",
        "name": "Intellectual disability",
        "systems": [
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        ],
        "url": "https://dantelabs.com/traits/intellectual-disability"
      },
      {
        "slug": "irritability",
        "name": "Irritability",
        "systems": [
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        ],
        "url": "https://dantelabs.com/traits/irritability"
      },
      {
        "slug": "lethargy",
        "name": "Lethargy",
        "systems": [
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        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/lethargy"
      },
      {
        "slug": "hypoargininemia",
        "name": "Low blood arginine levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hypoargininemia"
      },
      {
        "slug": "hypotonia",
        "name": "Low muscle tone",
        "systems": [
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        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hypotonia"
      },
      {
        "slug": "protein-avoidance",
        "name": "Protein avoidance",
        "systems": [
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        ],
        "url": "https://dantelabs.com/traits/protein-avoidance"
      },
      {
        "slug": "respiratory-alkalosis",
        "name": "Respiratory alkalosis",
        "systems": [
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        ],
        "url": "https://dantelabs.com/traits/respiratory-alkalosis"
      },
      {
        "slug": "respiratory-insufficiency",
        "name": "Respiratory function loss",
        "systems": [
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        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/respiratory-insufficiency"
      },
      {
        "slug": "stroke",
        "name": "Stroke",
        "systems": [
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          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/stroke"
      },
      {
        "slug": "vomiting",
        "name": "Vomiting",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "url": "https://dantelabs.com/traits/vomiting"
      }
    ],
    "related": [
      {
        "slug": "arg1",
        "symbol": "ARG1",
        "name": "arginase 1",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/arg1"
      },
      {
        "slug": "asl",
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        "name": "argininosuccinate lyase",
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        "url": "https://dantelabs.com/cs/genes/asl"
      },
      {
        "slug": "ass1",
        "symbol": "ASS1",
        "name": "argininosuccinate synthase 1",
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        "url": "https://dantelabs.com/cs/genes/ass1"
      },
      {
        "slug": "ca5a",
        "symbol": "CA5A",
        "name": "carbonic anhydrase 5A",
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        "url": "https://dantelabs.com/cs/genes/ca5a"
      },
      {
        "slug": "glud1",
        "symbol": "GLUD1",
        "name": "glutamate dehydrogenase 1",
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        "url": "https://dantelabs.com/cs/genes/glud1"
      },
      {
        "slug": "mccc1",
        "symbol": "MCCC1",
        "name": "methylcrotonyl-CoA carboxylase subunit 1",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/mccc1"
      },
      {
        "slug": "nags",
        "symbol": "NAGS",
        "name": "N-acetylglutamate synthase",
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        "url": "https://dantelabs.com/cs/genes/nags"
      },
      {
        "slug": "otc",
        "symbol": "OTC",
        "name": "ornithine transcarbamylase",
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        "url": "https://dantelabs.com/cs/genes/otc"
      },
      {
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        "symbol": "SLC25A13",
        "name": "solute carrier family 25 member 13",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/slc25a13"
      },
      {
        "slug": "slc25a15",
        "symbol": "SLC25A15",
        "name": "solute carrier family 25 member 15",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/slc25a15"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
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}