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        "frequency": "frequent",
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        "name": "Arterial dissection",
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        "frequency": "occasional",
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      {
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        "name": "Arterial rupture",
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        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/arterial-rupture"
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      {
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        "url": "https://dantelabs.com/traits/arteriovenous-fistula"
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        "url": "https://dantelabs.com/traits/bladder-diverticulum"
      },
      {
        "slug": "blepharochalasis",
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        "url": "https://dantelabs.com/traits/blepharochalasis"
      },
      {
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        "name": "Brain aneurysm",
        "systems": [
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          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/dilatation-of-the-cerebral-artery"
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      {
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        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/bruising-susceptibility"
      },
      {
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        "systems": [
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        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/aortic-root-aneurysm"
      },
      {
        "slug": "cervical-insufficiency",
        "name": "Cervical insufficiency",
        "systems": [
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        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cervical-insufficiency"
      },
      {
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        "name": "Chronic constipation",
        "systems": [
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        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/chronic-constipation"
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      {
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        "name": "Cigarette-paper scars",
        "systems": [
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          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/cigarette-paper-scars"
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      {
        "slug": "talipes-equinovarus",
        "name": "Club feet",
        "systems": [
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        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/talipes-equinovarus"
      },
      {
        "slug": "hemoptysis",
        "name": "Coughing up blood",
        "systems": [
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        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hemoptysis"
      },
      {
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        "name": "Decrease in blood pressure upon standing up",
        "systems": [
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          "abnormality-of-the-nervous-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/orthostatic-hypotension"
      },
      {
        "slug": "osteoarthritis",
        "name": "Degenerative joint disease",
        "systems": [
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        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/osteoarthritis"
      },
      {
        "slug": "congenital-hip-dislocation",
        "name": "Dislocated hip since birth",
        "systems": [
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          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/congenital-hip-dislocation"
      },
      {
        "slug": "patellar-dislocation",
        "name": "Dislocated kneecap",
        "systems": [
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        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/patellar-dislocation"
      },
      {
        "slug": "dislocated-radial-head",
        "name": "Dislocated radial head",
        "systems": [
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          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/dislocated-radial-head"
      },
      {
        "slug": "joint-hypermobility",
        "name": "Double-Jointed",
        "systems": [
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        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/joint-hypermobility"
      },
      {
        "slug": "pes-planus",
        "name": "Dropped arches",
        "systems": [
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        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/pes-planus"
      },
      {
        "slug": "ecchymosis",
        "name": "Ecchymosis",
        "systems": [
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          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ecchymosis"
      },
      {
        "slug": "epicanthus",
        "name": "Eye folds",
        "systems": [
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        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/epicanthus"
      },
      {
        "slug": "fatigue",
        "name": "Fatigue",
        "systems": [
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        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/fatigue"
      },
      {
        "slug": "fragile-skin",
        "name": "Fragile skin",
        "systems": [
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        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/fragile-skin"
      },
      {
        "slug": "headache",
        "name": "Headache",
        "systems": [
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        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/headache"
      },
      {
        "slug": "hernia",
        "name": "Hernia",
        "systems": [
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        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hernia"
      },
      {
        "slug": "hip-dislocation",
        "name": "Hip dislocation",
        "systems": [
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          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hip-dislocation"
      },
      {
        "slug": "hyperextensible-skin",
        "name": "Hyperelastic skin",
        "systems": [
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        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hyperextensible-skin"
      },
      {
        "slug": "generalized-joint-hypermobility",
        "name": "Hypermobility of all joints",
        "systems": [
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        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/generalized-joint-hypermobility"
      },
      {
        "slug": "incisional-hernia",
        "name": "Incisional hernia",
        "systems": [
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          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/incisional-hernia"
      },
      {
        "slug": "inguinal-hernia",
        "name": "Inguinal hernia",
        "systems": [
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          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/inguinal-hernia"
      },
      {
        "slug": "joint-dislocation",
        "name": "Joint dislocation",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/joint-dislocation"
      },
      {
        "slug": "arthralgia",
        "name": "Joint pain",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/arthralgia"
      },
      {
        "slug": "joint-swelling",
        "name": "Joint swelling",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/joint-swelling"
      },
      {
        "slug": "limb-pain",
        "name": "Limb pain",
        "systems": [
          "abnormality-of-the-musculoskeletal-system",
          "constitutional-symptom"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/limb-pain"
      },
      {
        "slug": "hypotonia",
        "name": "Low muscle tone",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/hypotonia"
      },
      {
        "slug": "mitral-regurgitation",
        "name": "Mitral regurgitation",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/mitral-regurgitation"
      },
      {
        "slug": "mitral-valve-prolapse",
        "name": "Mitral valve prolapse",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/mitral-valve-prolapse"
      },
      {
        "slug": "molluscoid-pseudotumors",
        "name": "Molluscoid pseudotumors",
        "systems": [
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        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/molluscoid-pseudotumors"
      },
      {
        "slug": "motor-delay",
        "name": "Motor delay",
        "systems": [
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        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/motor-delay"
      },
      {
        "slug": "muscle-spasm",
        "name": "Muscle spasm",
        "systems": [
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        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/muscle-spasm"
      },
      {
        "slug": "muscle-weakness",
        "name": "Muscle weakness",
        "systems": [
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        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/muscle-weakness"
      },
      {
        "slug": "nausea",
        "name": "Nausea",
        "systems": [
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        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/nausea"
      },
      {
        "slug": "osteopenia",
        "name": "Osteopenia",
        "systems": [
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        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/osteopenia"
      },
      {
        "slug": "acrocyanosis",
        "name": "Persistent blue color of hands or feet",
        "systems": [
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        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/acrocyanosis"
      },
      {
        "slug": "phalangeal-dislocation",
        "name": "Phalangeal dislocation",
        "systems": [
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          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/phalangeal-dislocation"
      },
      {
        "slug": "piezogenic-pedal-papules",
        "name": "Piezogenic pedal papules",
        "systems": [
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        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/piezogenic-pedal-papules"
      },
      {
        "slug": "poor-wound-healing",
        "name": "Poor wound healing",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/poor-wound-healing"
      },
      {
        "slug": "premature-birth",
        "name": "Premature birth",
        "systems": [
          "abnormality-of-prenatal-development-or-birth"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/premature-birth"
      },
      {
        "slug": "premature-rupture-of-membranes",
        "name": "Premature rupture of membranes",
        "systems": [
          "abnormality-of-prenatal-development-or-birth"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/premature-rupture-of-membranes"
      },
      {
        "slug": "prematurely-aged-appearance",
        "name": "Prematurely aged appearance",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/prematurely-aged-appearance"
      },
      {
        "slug": "prolonged-bleeding-time",
        "name": "Prolonged bleeding time",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/prolonged-bleeding-time"
      },
      {
        "slug": "pulp-calcification",
        "name": "Pulp stones",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/pulp-calcification"
      },
      {
        "slug": "rectal-prolapse",
        "name": "Rectum protrudes through anus",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/rectal-prolapse"
      },
      {
        "slug": "recurrent-joint-dislocation",
        "name": "Recurrent joint dislocation",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/recurrent-joint-dislocation"
      },
      {
        "slug": "recurrent-sinusitis",
        "name": "Recurrent sinus disease",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-immune-system",
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/recurrent-sinusitis"
      },
      {
        "slug": "uterine-prolapse",
        "name": "Sagging uterus",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/uterine-prolapse"
      },
      {
        "slug": "scoliosis",
        "name": "Scoliosis",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/scoliosis"
      },
      {
        "slug": "shoulder-dislocation",
        "name": "Shoulder dislocation",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/shoulder-dislocation"
      },
      {
        "slug": "soft-skin",
        "name": "Soft skin",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/soft-skin"
      },
      {
        "slug": "soft-doughy-skin",
        "name": "Soft, doughy skin",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/soft-doughy-skin"
      },
      {
        "slug": "hiatus-hernia",
        "name": "Stomach hernia",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hiatus-hernia"
      },
      {
        "slug": "striae-distensae",
        "name": "Stretch marks",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/striae-distensae"
      },
      {
        "slug": "subcutaneous-spheroids",
        "name": "Subcutaneous spheroids",
        "systems": [
          "abnormality-of-the-integument"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/subcutaneous-spheroids"
      },
      {
        "slug": "atrophic-scars",
        "name": "Sunken or indented skin due to damage",
        "systems": [
          "abnormality-of-the-integument",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/atrophic-scars"
      },
      {
        "slug": "tricuspid-valve-prolapse",
        "name": "Tricuspid valve prolapse",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/tricuspid-valve-prolapse"
      },
      {
        "slug": "umbilical-hernia",
        "name": "Umbilical hernia",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/umbilical-hernia"
      },
      {
        "slug": "vomiting",
        "name": "Vomiting",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/vomiting"
      }
    ],
    "related": [
      {
        "slug": "adamts2",
        "symbol": "ADAMTS2",
        "name": "ADAM metallopeptidase with thrombospondin type 1 motif 2",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/adamts2"
      },
      {
        "slug": "aebp1",
        "symbol": "AEBP1",
        "name": "AE binding protein 1",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/aebp1"
      },
      {
        "slug": "b3galt6",
        "symbol": "B3GALT6",
        "name": "beta-1,3-galactosyltransferase 6",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/b3galt6"
      },
      {
        "slug": "b4galt7",
        "symbol": "B4GALT7",
        "name": "beta-1,4-galactosyltransferase 7",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/b4galt7"
      },
      {
        "slug": "c1r",
        "symbol": "C1R",
        "name": "complement C1r",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/c1r"
      },
      {
        "slug": "c1s",
        "symbol": "C1S",
        "name": "complement C1s",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/c1s"
      },
      {
        "slug": "chst14",
        "symbol": "CHST14",
        "name": "carbohydrate sulfotransferase 14",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/chst14"
      },
      {
        "slug": "col12a1",
        "symbol": "COL12A1",
        "name": "collagen type XII alpha 1 chain",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/col12a1"
      },
      {
        "slug": "col1a1",
        "symbol": "COL1A1",
        "name": "collagen type I alpha 1 chain",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/col1a1"
      },
      {
        "slug": "col1a2",
        "symbol": "COL1A2",
        "name": "collagen type I alpha 2 chain",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/col1a2"
      },
      {
        "slug": "col3a1",
        "symbol": "COL3A1",
        "name": "collagen type III alpha 1 chain",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/col3a1"
      },
      {
        "slug": "col5a1",
        "symbol": "COL5A1",
        "name": "collagen type V alpha 1 chain",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/col5a1"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}