{
  "url": "https://dantelabs.com/cs/genes/cd59",
  "gene": {
    "slug": "cd59",
    "symbol": "CD59",
    "name": "CD59 molecule (CD59 blood group)",
    "hgnc": "HGNC:1689",
    "summary": null,
    "location": "11p13",
    "locusType": "gene with protein product",
    "aliases": [
      "16.3A5",
      "EJ16",
      "EJ30",
      "EL32",
      "G344",
      "p18-20"
    ],
    "previousSymbols": [
      "MIC11",
      "MIN1",
      "MSK21",
      "MIN2",
      "MIN3",
      "MIRL",
      "MACIF",
      "HRF20"
    ],
    "ensemblId": "ENSG00000085063",
    "entrezId": 966,
    "omim": [
      "107271"
    ],
    "uniprot": [
      "P13987"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "11",
      "start": 33703010,
      "end": 33736423,
      "strand": "-",
      "ensemblTranscript": "ENST00000642928.2",
      "refseqTranscript": "NM_000611.6",
      "ensemblProtein": "ENSP00000494884.1",
      "refseqProtein": "NP_000602.1",
      "exons": [
        {
          "start": 33703010,
          "end": 33710343
        },
        {
          "start": 33717370,
          "end": 33717471
        },
        {
          "start": 33722379,
          "end": 33722463
        },
        {
          "start": 33736382,
          "end": 33736423
        }
      ],
      "cds": {
        "start": 33710126,
        "end": 33722445
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "11",
      "start": 33719807,
      "end": 33757991,
      "strand": "-"
    },
    "neighbourhood": {
      "release": "116",
      "start": 33219717,
      "end": 34219716,
      "genes": [
        {
          "symbol": "HIPK3",
          "ensemblId": "ENSG00000110422",
          "biotype": "protein_coding",
          "start": 33256672,
          "end": 33357023,
          "strand": "+",
          "slug": "hipk3"
        },
        {
          "symbol": "KIAA1549L",
          "ensemblId": "ENSG00000110427",
          "biotype": "protein_coding",
          "start": 33376078,
          "end": 33674102,
          "strand": "+",
          "slug": "kiaa1549l"
        },
        {
          "symbol": "C11orf91",
          "ensemblId": "ENSG00000205177",
          "biotype": "protein_coding",
          "start": 33698261,
          "end": 33700826,
          "strand": "-",
          "slug": "c11orf91"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000284969",
          "biotype": "protein_coding",
          "start": 33698261,
          "end": 33722467,
          "strand": "-"
        },
        {
          "symbol": "FBXO3",
          "ensemblId": "ENSG00000110429",
          "biotype": "protein_coding",
          "start": 33739834,
          "end": 33774543,
          "strand": "-",
          "slug": "fbxo3"
        },
        {
          "symbol": "LMO2",
          "ensemblId": "ENSG00000135363",
          "biotype": "protein_coding",
          "start": 33858563,
          "end": 33892076,
          "strand": "-",
          "slug": "lmo2"
        },
        {
          "symbol": "CAPRIN1",
          "ensemblId": "ENSG00000135387",
          "biotype": "protein_coding",
          "start": 34051649,
          "end": 34103835,
          "strand": "+",
          "slug": "caprin1"
        },
        {
          "symbol": "NAT10",
          "ensemblId": "ENSG00000135372",
          "biotype": "protein_coding",
          "start": 34105583,
          "end": 34147670,
          "strand": "+",
          "slug": "nat10"
        },
        {
          "symbol": "ABTB2",
          "ensemblId": "ENSG00000166016",
          "biotype": "protein_coding",
          "start": 34150987,
          "end": 34358043,
          "strand": "-",
          "slug": "abtb2"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "rare-hereditary-peripheral-neuropathies",
        "name": "Rare Hereditary Peripheral Neuropathies",
        "diseases": [
          {
            "mondoId": "MONDO:0020127",
            "name": "Hereditary Peripheral Neuropathy",
            "genes": 233,
            "inheritance": null,
            "description": "Caused by changes in one of many genes needed to keep long nerve fibres healthy. In this report these include IGHMBP2 and PLEKHG5, which are recessive.",
            "management": "Physiotherapy, orthoses and occupational therapy help maintain mobility, with surgery for foot deformities when needed. Some forms need breathing monitoring. Genetic counselling guides family testing according to the inheritance pattern of the gene involved.",
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": true
          }
        ],
        "url": "https://dantelabs.com/cs/conditions/rare-hereditary-peripheral-neuropathies"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "areflexia",
        "name": "Absent reflexes",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/areflexia"
      },
      {
        "slug": "generalized-hypotonia",
        "name": "Generalized decreased muscle tone",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/generalized-hypotonia"
      },
      {
        "slug": "hemolytic-anemia",
        "name": "Hemolytic anemia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "url": "https://dantelabs.com/traits/hemolytic-anemia"
      },
      {
        "slug": "increased-csf-protein-concentration",
        "name": "Increased CSF protein concentration",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/increased-csf-protein-concentration"
      },
      {
        "slug": "limb-muscle-weakness",
        "name": "Limb muscle weakness",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/limb-muscle-weakness"
      },
      {
        "slug": "hypotonia",
        "name": "Low muscle tone",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/hypotonia"
      },
      {
        "slug": "skeletal-muscle-atrophy",
        "name": "Muscle degeneration",
        "systems": [
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/skeletal-muscle-atrophy"
      },
      {
        "slug": "paralysis",
        "name": "Paralysis",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/paralysis"
      },
      {
        "slug": "paroxysmal-nocturnal-hemoglobinuria",
        "name": "Paroxysmal nocturnal hemoglobinuria",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/paroxysmal-nocturnal-hemoglobinuria"
      },
      {
        "slug": "polyneuropathy",
        "name": "Peripheral nerve disease",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/polyneuropathy"
      }
    ],
    "related": [
      {
        "slug": "aars1",
        "symbol": "AARS1",
        "name": "alanyl-tRNA synthetase 1",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/aars1"
      },
      {
        "slug": "abhd12",
        "symbol": "ABHD12",
        "name": "abhydrolase domain containing 12, lysophospholipase",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/abhd12"
      },
      {
        "slug": "aifm1",
        "symbol": "AIFM1",
        "name": "apoptosis inducing factor mitochondria associated 1",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/aifm1"
      },
      {
        "slug": "apoa1",
        "symbol": "APOA1",
        "name": "apolipoprotein A1",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/apoa1"
      },
      {
        "slug": "arsa",
        "symbol": "ARSA",
        "name": "arylsulfatase A",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/arsa"
      },
      {
        "slug": "atl1",
        "symbol": "ATL1",
        "name": "atlastin GTPase 1",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/atl1"
      },
      {
        "slug": "atl3",
        "symbol": "ATL3",
        "name": "atlastin GTPase 3",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/atl3"
      },
      {
        "slug": "atp1a1",
        "symbol": "ATP1A1",
        "name": "ATPase Na+/K+ transporting subunit alpha 1",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/atp1a1"
      },
      {
        "slug": "atp5mk",
        "symbol": "ATP5MK",
        "name": "ATP synthase membrane subunit k",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/atp5mk"
      },
      {
        "slug": "atp7a",
        "symbol": "ATP7A",
        "name": "ATPase copper transporting alpha",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/atp7a"
      },
      {
        "slug": "bicd2",
        "symbol": "BICD2",
        "name": "BICD cargo adaptor 2",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/bicd2"
      },
      {
        "slug": "bscl2",
        "symbol": "BSCL2",
        "name": "BSCL2 lipid droplet biogenesis associated, seipin",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/bscl2"
      }
    ],
    "sources": {
      "bundleId": "2026.10.18-8b139e39",
      "panel": "2026-10-18",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}