{
  "url": "https://dantelabs.com/cs/genes/cd55",
  "gene": {
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    "symbol": "CD55",
    "name": "CD55 molecule (Cromer blood group)",
    "hgnc": "HGNC:2665",
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    "locusType": "gene with protein product",
    "aliases": [
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      "CROM"
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    "omim": [
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    "uniprot": [
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      "start": 207321678,
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      "strand": "+",
      "ensemblTranscript": "ENST00000367064.9",
      "refseqTranscript": "NM_000574.5",
      "ensemblProtein": "ENSP00000356031.4",
      "refseqProtein": "NP_000565.1",
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      "strand": "+"
    },
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      "genes": [
        {
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          "ensemblId": "ENSG00000142224",
          "biotype": "protein_coding",
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          "end": 206842981,
          "strand": "+",
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        {
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        {
          "symbol": "IL24",
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        {
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        {
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          "strand": "-",
          "slug": "pigr"
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        {
          "symbol": "FCAMR",
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          "biotype": "protein_coding",
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          "end": 206970625,
          "strand": "-",
          "slug": "fcamr"
        },
        {
          "symbol": "C1orf116",
          "ensemblId": "ENSG00000182795",
          "biotype": "protein_coding",
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          "end": 207032821,
          "strand": "-",
          "slug": "c1orf116"
        },
        {
          "symbol": "PFKFB2",
          "ensemblId": "ENSG00000123836",
          "biotype": "protein_coding",
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          "end": 207081243,
          "strand": "+",
          "slug": "pfkfb2"
        },
        {
          "symbol": "YOD1",
          "ensemblId": "ENSG00000180667",
          "biotype": "protein_coding",
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          "strand": "-",
          "slug": "yod1"
        },
        {
          "symbol": "C4BPB",
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          "biotype": "protein_coding",
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          "end": 207100001,
          "strand": "+",
          "slug": "c4bpb"
        },
        {
          "symbol": "C4BPA",
          "ensemblId": "ENSG00000123838",
          "biotype": "protein_coding",
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          "end": 207145047,
          "strand": "+",
          "slug": "c4bpa"
        },
        {
          "symbol": "CR2",
          "ensemblId": "ENSG00000117322",
          "biotype": "protein_coding",
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          "strand": "+",
          "slug": "cr2"
        },
        {
          "symbol": "CR1",
          "ensemblId": "ENSG00000203710",
          "biotype": "protein_coding",
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          "end": 207641776,
          "strand": "+",
          "slug": "cr1"
        },
        {
          "symbol": "CR1L",
          "ensemblId": "ENSG00000197721",
          "biotype": "protein_coding",
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          "end": 207738416,
          "strand": "+",
          "slug": "cr1l"
        },
        {
          "symbol": "CD46",
          "ensemblId": "ENSG00000117335",
          "biotype": "protein_coding",
          "start": 207752037,
          "end": 207795516,
          "strand": "+",
          "slug": "cd46"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "chaple-disease",
        "name": "CHAPLE Disease (CD55 Deficiency)",
        "diseases": [
          {
            "mondoId": "MONDO:0009174",
            "name": "CHAPLE disease (CD55-deficient protein-losing enteropathy)",
            "genes": 1,
            "inheritance": "autosomal-recessive",
            "description": "Complement hyperactivation, angiopathic thrombosis and protein-losing enteropathy caused by loss of CD55.",
            "management": "Complement-blocking treatment, including pozelimab, which the FDA approved for this condition in 2023, can control the disease.",
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)"
              ],
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/cs/conditions/chaple-disease"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "abdominal-pain",
        "name": "Abdominal pain",
        "systems": [
          "abnormality-of-the-digestive-system",
          "constitutional-symptom"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/abdominal-pain"
      },
      {
        "slug": "abnormal-intestine-morphology",
        "name": "Abnormality of the intestine",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "url": "https://dantelabs.com/traits/abnormal-intestine-morphology"
      },
      {
        "slug": "ascites",
        "name": "Accumulation of fluid in the abdomen",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "url": "https://dantelabs.com/traits/ascites"
      },
      {
        "slug": "pulmonary-embolism",
        "name": "Blood clot in artery of lung",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-respiratory-system"
        ],
        "url": "https://dantelabs.com/traits/pulmonary-embolism"
      },
      {
        "slug": "hepatic-vein-thrombosis",
        "name": "Blood clot in liver vein",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hepatic-vein-thrombosis"
      },
      {
        "slug": "budd-chiari-syndrome",
        "name": "Budd-Chiari syndrome",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/budd-chiari-syndrome"
      },
      {
        "slug": "clubbing-of-fingers",
        "name": "Clubbing of fingers",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/clubbing-of-fingers"
      },
      {
        "slug": "clubbing",
        "name": "Clubbing of fingers and toes",
        "systems": [
          "abnormality-of-limbs",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/clubbing"
      },
      {
        "slug": "decreased-circulating-immunoglobulin-concentration",
        "name": "Decreased circulating antibody level",
        "systems": [
          "abnormal-cellular-phenotype",
          "abnormality-of-blood-and-blood-forming-tissues",
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/decreased-circulating-immunoglobulin-concentration"
      },
      {
        "slug": "hypoproteinemia",
        "name": "Decreased protein levels in blood",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/hypoproteinemia"
      },
      {
        "slug": "diarrhea",
        "name": "Diarrhea",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/diarrhea"
      },
      {
        "slug": "hepatomegaly",
        "name": "Enlarged liver",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "url": "https://dantelabs.com/traits/hepatomegaly"
      },
      {
        "slug": "edema",
        "name": "Fluid retention",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/edema"
      },
      {
        "slug": "generalized-edema",
        "name": "Generalized edema",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/generalized-edema"
      },
      {
        "slug": "growth-delay",
        "name": "Growth delay",
        "systems": [
          "growth-abnormality"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/growth-delay"
      },
      {
        "slug": "thrombocytosis",
        "name": "Increased number of platelets in blood",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/thrombocytosis"
      },
      {
        "slug": "intestinal-lymphangiectasia",
        "name": "Intestinal lymphangiectasia",
        "systems": [
          "abnormality-of-the-cardiovascular-system",
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/intestinal-lymphangiectasia"
      },
      {
        "slug": "intestinal-obstruction",
        "name": "Intestinal obstruction",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "url": "https://dantelabs.com/traits/intestinal-obstruction"
      },
      {
        "slug": "iron-deficiency-anemia",
        "name": "Iron deficiency anemia",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "url": "https://dantelabs.com/traits/iron-deficiency-anemia"
      },
      {
        "slug": "arthralgia",
        "name": "Joint pain",
        "systems": [
          "constitutional-symptom"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/arthralgia"
      },
      {
        "slug": "hypoalbuminemia",
        "name": "Low albumin",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/hypoalbuminemia"
      },
      {
        "slug": "anemia",
        "name": "Low number of red blood cells or hemoglobin",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/anemia"
      },
      {
        "slug": "malabsorption",
        "name": "Malabsorption",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/malabsorption"
      },
      {
        "slug": "protein-losing-enteropathy",
        "name": "Protein-losing enteropathy",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/protein-losing-enteropathy"
      },
      {
        "slug": "recurrent-lower-respiratory-tract-infections",
        "name": "Recurrent chest infections",
        "systems": [
          "abnormality-of-the-immune-system",
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/recurrent-lower-respiratory-tract-infections"
      },
      {
        "slug": "recurrent-infections",
        "name": "Recurrent infections",
        "systems": [
          "abnormality-of-the-immune-system"
        ],
        "url": "https://dantelabs.com/traits/recurrent-infections"
      },
      {
        "slug": "hypothyroidism",
        "name": "Underactive thyroid",
        "systems": [
          "abnormality-of-the-endocrine-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/hypothyroidism"
      },
      {
        "slug": "vomiting",
        "name": "Vomiting",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/vomiting"
      }
    ],
    "related": [],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}