{
  "url": "https://dantelabs.com/cs/genes/arhgdia",
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      ],
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    "reports": [
      {
        "slug": "nephrotic-syndrome",
        "name": "Nephrotic Syndrome",
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          {
            "mondoId": "MONDO:0002331",
            "name": "Nephrosis",
            "genes": 29,
            "inheritance": null,
            "description": "Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secondary complication of other diseases. It is characterized by the NEPHROTIC SYNDROME indicating the presence of PROTEINURIA and HYPOALBUMINEMIA with accompanying EDEMA.",
            "management": null,
            "evidence": {
              "gencc": [
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
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              "clingen": "Moderate",
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              "inheritance": [
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            },
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        ],
        "url": "https://dantelabs.com/cs/conditions/nephrotic-syndrome"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
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        "name": "Abdominal pain",
        "systems": [
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          "constitutional-symptom"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/abdominal-pain"
      },
      {
        "slug": "abnormality-of-the-nervous-system",
        "name": "Abnormality of the nervous system",
        "systems": [],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/abnormality-of-the-nervous-system"
      },
      {
        "slug": "cerebral-visual-impairment",
        "name": "Cerebral visual impairment",
        "systems": [
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        ],
        "url": "https://dantelabs.com/traits/cerebral-visual-impairment"
      },
      {
        "slug": "chronic-kidney-disease",
        "name": "Chronic kidney disease",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/chronic-kidney-disease"
      },
      {
        "slug": "diffuse-mesangial-sclerosis",
        "name": "Diffuse mesangial sclerosis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/diffuse-mesangial-sclerosis"
      },
      {
        "slug": "seizure",
        "name": "Epilepsy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/seizure"
      },
      {
        "slug": "fever",
        "name": "Fever",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/fever"
      },
      {
        "slug": "edema",
        "name": "Fluid retention",
        "systems": [
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        ],
        "frequency": "very-frequent",
        "url": "https://dantelabs.com/traits/edema"
      },
      {
        "slug": "foamy-urine",
        "name": "Foamy urine",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/foamy-urine"
      },
      {
        "slug": "focal-segmental-glomerulosclerosis",
        "name": "Focal segmental glomerulosclerosis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/focal-segmental-glomerulosclerosis"
      },
      {
        "slug": "generalized-edema",
        "name": "Generalized edema",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/generalized-edema"
      },
      {
        "slug": "headache",
        "name": "Headache",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/headache"
      },
      {
        "slug": "proteinuria",
        "name": "High urine protein levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/proteinuria"
      },
      {
        "slug": "intellectual-disability",
        "name": "Intellectual disability",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/intellectual-disability"
      },
      {
        "slug": "irritability",
        "name": "Irritability",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/irritability"
      },
      {
        "slug": "hypoalbuminemia",
        "name": "Low albumin",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hypoalbuminemia"
      },
      {
        "slug": "minimal-change-glomerulonephritis",
        "name": "Minimal change glomerulonephritis",
        "systems": [
          "abnormality-of-the-genitourinary-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/minimal-change-glomerulonephritis"
      },
      {
        "slug": "nephrotic-syndrome",
        "name": "Nephrotic syndrome",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/nephrotic-syndrome"
      },
      {
        "slug": "periorbital-edema",
        "name": "Periorbital edema",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-metabolism-homeostasis"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/periorbital-edema"
      },
      {
        "slug": "peritonitis",
        "name": "Peritonitis",
        "systems": [
          "abnormality-of-the-digestive-system",
          "abnormality-of-the-immune-system"
        ],
        "frequency": "very-rare",
        "url": "https://dantelabs.com/traits/peritonitis"
      },
      {
        "slug": "respiratory-tract-infection",
        "name": "Respiratory tract infection",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/respiratory-tract-infection"
      },
      {
        "slug": "sensorineural-hearing-impairment",
        "name": "Sensorineural hearing impairment",
        "systems": [
          "abnormality-of-the-ear"
        ],
        "url": "https://dantelabs.com/traits/sensorineural-hearing-impairment"
      },
      {
        "slug": "stage-5-chronic-kidney-disease",
        "name": "Stage 5 chronic kidney disease",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/stage-5-chronic-kidney-disease"
      },
      {
        "slug": "thin-glomerular-basement-membrane",
        "name": "Thin glomerular basement membrane",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/thin-glomerular-basement-membrane"
      }
    ],
    "related": [
      {
        "slug": "actn4",
        "symbol": "ACTN4",
        "name": "actinin alpha 4",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/actn4"
      },
      {
        "slug": "coq6",
        "symbol": "COQ6",
        "name": "coenzyme Q6, monooxygenase",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/coq6"
      },
      {
        "slug": "coq8b",
        "symbol": "COQ8B",
        "name": "coenzyme Q8B",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/coq8b"
      },
      {
        "slug": "daam2",
        "symbol": "DAAM2",
        "name": "dishevelled associated activator of morphogenesis 2",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/daam2"
      },
      {
        "slug": "dgke",
        "symbol": "DGKE",
        "name": "diacylglycerol kinase epsilon",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/dgke"
      },
      {
        "slug": "dlc1",
        "symbol": "DLC1",
        "name": "DLC1 Rho GTPase activating protein",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/dlc1"
      },
      {
        "slug": "emp2",
        "symbol": "EMP2",
        "name": "epithelial membrane protein 2",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/emp2"
      },
      {
        "slug": "itsn1",
        "symbol": "ITSN1",
        "name": "intersectin 1",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/itsn1"
      },
      {
        "slug": "itsn2",
        "symbol": "ITSN2",
        "name": "intersectin 2",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/itsn2"
      },
      {
        "slug": "kank2",
        "symbol": "KANK2",
        "name": "KN motif and ankyrin repeat domains 2",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/kank2"
      },
      {
        "slug": "lama5",
        "symbol": "LAMA5",
        "name": "laminin subunit alpha 5",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/lama5"
      },
      {
        "slug": "lamb2",
        "symbol": "LAMB2",
        "name": "laminin subunit beta 2",
        "shared": 1,
        "url": "https://dantelabs.com/cs/genes/lamb2"
      }
    ],
    "sources": {
      "bundleId": "2026.10.16-c6eea6bf",
      "panel": "2026-10-16",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}